Ophthotech Reports Third Quarter 2015 Financial and Operating Results

– Conference Call and Webcast Today, November 5, 2015, at 8:00 a.m.
ET –

NEW YORK–(BUSINESS WIRE)–Ophthotech Corporation (Nasdaq:OPHT) today announced financial results
for the third quarter ended September 30, 2015 and provided an update on
the Company’s business and product development programs.

“We have achieved many significant milestones that have us on track to
reach our goal to provide initial, topline data from both Phase 3 trials
of Fovista^® in combination with Lucentis in the fourth
quarter of 2016,” said David R. Guyer, M.D., Chief Executive Officer and
Chairman of the Board of Ophthotech.

Ophthotech Highlights

• In October 2015, Ophthotech announced the completion of patient
  recruitment in its second Phase 3 trial of Fovista^®
  (pegpleranib) in combination with Lucentis^® (ranibizumab)
  for the treatment of wet age-related macular degeneration (AMD). The
  Company expects to announce initial, topline data from both Phase 3
  trials of Fovista^® in combination with Lucentis^®
  in the fourth quarter of 2016. A third Phase 3 trial, which is
  investigating Fovista^® in combination with either Eylea^®
  (aflibercept) or Avastin^® (bevacizumab), continues to
  enroll patients and is on track.
• Recruitment has been completed in two of the Fovista^®
  Expansion Studies. These trials are investigating the optimal regimen
  for Fovista^® administration in combination with multiple
  anti-VEGF agents to potentially reduce sub-retinal fibrosis and
  treatment burden in wet AMD patients. Both trials are ongoing and
  progressing well.

“This is an exciting time for Ophthotech as we approach the end of
2015,” stated Samir Patel, M.D., President and Vice-Chairman of the
Board of Ophthotech. “We continue to make excellent progress on our
Fovista^® expansion studies and, in particular, in our
anti-fibrosis program with respect to which we look forward to reporting
interim data by the end of the year. Additionally, our plans to initiate
a Phase 2/3 dry AMD program with Zimura^® by the end of the
year continue to be on track.”

Third Quarter Financial Highlights

• Cash Position: As of September 30, 2015, the Company had $426.0
  million in cash, cash equivalents, and marketable securities.
• Revenues: Collaboration revenue was $3.4 million for the
  quarter ended September 30, 2015, compared to $39.6 million for the
  prior year period. For the nine months ended September 30, 2015,
  collaboration revenue was $46.7 million compared to $39.6 million for
  the same period in 2014. Collaboration revenue recognized in 2015 and
  2014 consists of license fee revenue primarily attributable to the
  $50.0 million enrollment-based milestones the Company achieved in
  March 2015 and September 2014 under the Company’s Licensing and
  Commercialization Agreement with Novartis Pharma AG, as well as
  revenue associated with research and development activities the
  Company performs under the same agreement.
• R&D Expenses: Research and development expenses were $40.5
  million for the quarter ended September 30, 2015 compared to $17.1
  million for the same period in 2014. For the nine months ended
  September 30, 2015 research and development expenses were $97.1
  million compared to $66.2 million for the same period in 2014. The
  nine months ended September 30, 2014 included a $19.8 million
  milestone payment the Company paid in connection with entering into
  the agreement with Novartis. Excluding this milestone payment,
  research and development expense increased in both the quarter and
  nine months ended September 30, 2015 primarily due to the Company’s
  Fovista^® Phase 3 clinical program and increased personnel
  costs associated with additional management and research and
  development staffing, including share-based compensation expense.
• G&A Expenses: General and administrative expenses were
  $10.4 million for the quarter ended September 30, 2015 compared to
  $8.8 million for the same period in 2014. For the nine months ended
  September 30, 2015, general and administrative expenses were $32.0
  million compared to $22.7 million for the same period in 2014. The
  increase in general and administrative expenses in the quarter and
  nine months ended September 30, 2015 relates primarily to an increase
  in costs to support the Company’s expanded operations and public
  company infrastructure, including additional management, corporate
  staffing, professional services and consulting fees, and increased
  share-based compensation.
• Net Loss: The Company reported a net loss for the quarter ended
  September 30, 2015 of $39.6 million, or ($1.14) per diluted share.
  During September 2014, the Company achieved a $50.0 million
  enrollment-based milestone under Ophthotech’s agreement with Novartis
  which resulted in the Company recording net income of $8.6 million, or
  $0.25 per diluted share for the quarter ended September 30, 2014.

Conference Call/Web Cast Information

Ophthotech will host a conference call/audio webcast to discuss this
announcement. The call is scheduled for November 5, 2015 at 8:00 a.m.
Eastern Time. To participate in this conference call, dial 888-539-3678
(USA) or 719-457-2661 (International), passcode 270112. A live,
listen-only audio webcast of the conference call can be accessed on the
Investor Relations section of the Ophthotech website at: www.ophthotech.com.
A replay will be available approximately two hours following the live
call for two weeks. The replay number is (888) 203-1112 (USA Toll Free),
passcode 270112. The audio webcast can be accessed at: www.ophthotech.com.

About Ophthotech Corporation

Ophthotech is a biopharmaceutical company specializing in the
development of novel therapeutics to treat back of the eye diseases,
with a focus on developing innovative therapies for age-related macular
degeneration (AMD). Ophthotech’s most advanced product candidate, Fovista^®
anti-PDGF therapy, is in Phase 3 clinical trials for use in combination
with anti-VEGF therapy that represents the current standard of care for
the treatment of wet AMD. Ophthotech’s second product candidate, Zimura^®,
an inhibitor of complement factor C5, is being developed for the
treatment of geographic atrophy, a form of dry AMD. For more
information, please visit www.ophthotech.com.

Forward-looking Statements

Any statements in this press release about Ophthotech’s future
expectations, plans and prospects constitute forward-looking statements
for purposes of the safe harbor provisions under the Private Securities
Litigation Reform Act of 1995. Forward-looking statements include any
statements about Ophthotech’s strategy, future operations and future
expectations and plans and prospects for Ophthotech, and any other
statements containing the words “anticipate,” “believe,” “estimate,”
“expect,” “intend”, “goal,” “may”, “might,” “plan,” “predict,”
“project,” “target,” “potential,” “will,” “would,” “could,” “should,”
“continue,” and similar expressions. In this press release, Ophthotech’s
forward looking statements include statements about the timing and
progress of the Fovista^® Phase 3 clinical program and
Fovista^® expansion studies, including the
timing of completion of enrollment for these trials, the timing of
obtaining initial, topline data or interim data from these trials, the
timing of seeking marketing approval for Fovista^®, the
potential of Fovista^® as a wet AMD combination
therapy, and the initiation of additional trials for Fovista^® and
Zimura^®. Such forward-looking statements involve
substantial risks and uncertainties that could cause Ophthotech’s
clinical development programs, future results, performance or
achievements to differ significantly from those expressed or implied by
the forward-looking statements. Such risks and uncertainties include,
among others, those related to the initiation and conduct of clinical
trials, availability of data from clinical trials and expectations for
regulatory approvals or other actions and other factors discussed in the
“Risk Factors” section contained in the quarterly and annual reports
that Ophthotech files with the SEC. Any forward-looking statements
represent Ophthotech’s views only as of the date of this press release.
Ophthotech anticipates that subsequent events and developments will
cause its views to change. While Ophthotech may elect to update these
forward-looking statements at some point in the future, Ophthotech
specifically disclaims any obligation to do so except as required by law.

OPHT-G

Ophthotech Corporation
Selected Financial Data (unaudited)
(in thousands, except per share data)
						Three Months Ended September 30,															Nine Months Ended September 30,
						2015							2014								2015							2014
Statement of Operations Data:
Collaboration revenue						$		3,448					$			39,575					$		46,723					$		39,575
Operating expenses:
Research and development								40,479								17,105							97,095							66,189
General and administrative								10,412								8,812							31,955							22,731
Total operating expenses								50,891								25,917							129,050							88,920
Income (loss) from operations								(47,443	)							13,658							(82,327	)						(49,345	)
Interest income and other								339								73							630							189
Income (loss) before income tax provision								(47,104	)							13,731							(81,697	)						(49,156	)
Income tax (benefit) provision								(7,531	)							5,179							(11,629	)						35,964
Net income (loss)						$		(39,573	)				$			8,552					$		(70,068	)				$		(85,120	)
Net income (loss) per common share:
Basic						$		(1.14	)				$			0.26					$		(2.03	)				$		(2.57	)
Diluted						$		(1.14	)				$			0.25					$		(2.03	)				$		(2.57	)
Weighted average common shares outstanding:
Basic								34,782								33,531							34,432							33,074
Diluted								34,782								34,859							34,432							33,074
																					September 30, 2015							December 31, 2014
																					(in thousands)
Balance sheet data:
Cash, cash equivalents, and marketable securities																					$		425,986					$		463,560
Total assets																					$		450,751					$		479,786
Royalty purchase liability																					$		125,000					$		125,000
Deferred revenue																					$		214,710					$		209,624
Total liabilities																					$		367,640					$		351,249
Additional paid-in capital																					$		452,887					$		428,390
Accumulated deficit																					$		(369,890	)				$		(299,822	)
Total stockholders’ equity																					$		83,111					$		128,537

Contacts

Investors
Ophthotech Corporation
Kathy Galante,
212-845-8231
Vice President, Investor Relations and Corporate
Communications
kathy.galante@ophthotech.com
or
Media
SmithSolve
LLC on behalf of Ophthotech Corporation
Jennifer Devine,
973-442-1555
jennifer.devine@smithsolve.com