Age-Related Macular Degeneration – Market Trends and Forecasts: Technavio

LONDON–(BUSINESS WIRE)–$NOVN #AMD–Technavio’s latest report on the global
age-related macular degeneration (AMD) market
an analysis on the most important trends expected to impact the market
outlook from 2016-2020. Technavio
defines an emerging trend as a factor that has the potential to
significantly impact the market and contribute to its growth or decline.

Sapna Jha, a lead analyst from Technavio, specializing in research on cardiovascular
and metabolic disorders
sector, says, “AMD is an eye
defect that affects the tiny part of the retina at the back of the eye
called the macula. There are two types of AMD, namely dry and wet, which
affects mostly people over 60 years of age and, if AMD is left
untreated, it can lead to permanent vision loss

Special regulatory and fast track drug designations will act as a
major boost to the AMD market during the forecast period. Such
incentives have two-pronged benefits to the underlying vendors. First,
they can launch their drugs into the market through quicker channels,
and second, they get the tax benefits released by the respective
governments under such schemes. For example, Ophthotech’s Fovista
received fast-track designation from the US FDA and is expected to
launch by 2018. Once launched, it is expected to get a high market share
and will give strong competition to currently marketed drugs.

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The top three emerging trends driving the global AMD market according
to Technavio healthcare
and life sciences
research analysts are:

  • Novel treatment approaches for developing AMD drugs
  • Increased research grants, initiatives, and programs
  • Use of combination therapies

Novel treatment approaches for developing AMD drugs

The global AMD
market is witnessing better treatment options for macular degeneration,
which are expected to display promising results in the future. New
research into the effects of the tissue inhibitor of metalloproteinase-3
could lead to the development of novel medicines to treat
AMD. Also, two research groups with RNAi projects are looking into the
possibility of silencing the genes for VEGF in AMD. Once
confirmed, this new approach will open up for research in new medicines.

Similarly, ongoing research on mice proven better, more lasting
treatment for macular degeneration, which uses a class of drugs known as
murine double minute 2 inhibitors to degenerate the abnormal
blood vessels responsible for the vision loss associated with AMD. The
advantage that MDM2 inhibitors have over anti-VEGF is that
they aim the leaky blood vessels straight away, whereas anti-VEGF
targets the growth factors that lead to abnormal blood vessels
according to Sapna.

Increased research grants, initiatives, and programs

Due to increase in the R&D activities in the treatment of AMD, various
foundations offer grants to a researcher working in basic research in
the understanding of AMD and also to the researcher working in
translational AMD research focusing on therapeutics. For instance, the
Macular Degeneration Foundation provides financial support to
researchers investigating the treatment and helping those coping with
the challenges associated with AMD.

The overall public awareness of the problems related to visual
impairment has increased over the last decade because of the rise in the
number of initiatives taken by governments and various organizations.
The WHO, along with The International Agency for the Prevention of
Blindness (IAPB), initiated the Vision 2020: The Right to Sight program
in 2007.

Use of combination therapies

The AMD market is experiencing a shift toward combination products,
using two or more effective treatments. Parallel with the introduction
of novel, potent monotherapies for AMD, the market is facing a clear
trend toward individualized medicine. The shortcomings of treatment with
a single drug can overcome with the use of combination therapy.
With AMD, this may mean combination therapy. The need for practical
combination therapy exists to address these shortcomings of monotherapy.
The goal of combination therapy is to disrupt the multiple stimuli that
lead to pathologic cellular proliferation.

The key vendors are as follows:

  • Bayer HealthCare
  • F. Hoffmann-La Roche
  • Novartis
  • Regeneron Pharmaceuticals

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